The English civil war started in the summer of 1642.
The following excellent account comes from the Radical Manchester site:
On 15 July 1642 a party of Royalists led by Lord Strange came to Manchester and a fight broke out during which Richard Perceval, a linen weaver from Levenshulme, was killed, allegedly by Thomas Tyldesley from Astley. This has been claimed as the first death in a conflict which eventually claimed tens of thousands of lives.
By September Lord Strange had gathered several thousand troops in Warrington, while Manchester had a militia raised from the townspeople under the command of Colonel John Rosworm, a German soldier living in Manchester who had served in the Low Countries and Ireland and been taken on for six months to organise the town’s defences.
Strange moved out of Warrington on 24 September and laid siege to the town. The alarm was sounded by ringing the church bells. The Royalist headquarters were in Alport Lodge on Deansgate near what is now St John Street. The town refused to surrender and on 26 September the Royalists attacked down Deansgate, firing their cannon. They were driven off after some fierce fighting. They then attacked across Salford bridge but were held back as the defenders were on higher ground in the churchyard.
There was more fighting the following day but the again the attackers were repulsed. A truce was called and further talks took place but again the town, though running short of ammunition, refused Strange’s demands, though there were some divisions in the town.
On 29 September there was another round of fighting in which 200 Parliamentarians sallied out to attack a house on Deansgate which had been occupied by the Royalists . There was an hour of fighting in which the Royalists were defeated. A sniper on top of the church shot dead the Royalist Captain Standish who was standing in the door of a house on the Salford side of the river.
There was more fighting the next day. On 1 October there was an exchange of prisoners and Lord Strange and his troops abandoned the siege. In the course of the week’s skirmishes the Royalists appeared to have lost about 200 men and the defenders about 20. The victory at Manchester greatly boosted the moral of Parliament’s supporters in Lancashire. There was no further fighting in Manchester for the rest of the Civil War.